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Home >> Products >>Bioculture Products >>Advanced Bioreactor >> Automatic Bioreactor (CGMP compliant) 50L -1000L
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Automatic Bioreactor (CGMP compliant) 50L -1000L

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Automatic Bioreactor (CGMP compliant) 

50L -1000L


50 liter bacterial vaccine fermenter BLBIO-50V-GMP


200L Automatic Vaccine Fermenter (GMP)


300L Automatic Vaccine Fermenter (GMP)


100L900L pertussis bacterial vaccine fermenter


100L1400L bacterial pneumonia automatic fermenter


BLBIO-XV-GMP series fermenters are bacterial culture equipment that fully comply with GMP requirements, and the whole process meets the requirements of hygiene: fully sealed, zero leakage, no pollution, and maintenance-free. It completely solves the problem of bacterial infection in the culture of biological product tanks. Fermentation parameters such as pH, DO, temperature and speed can be monitored by the controller, and all data and control parameters can be transferred to the controller or computer. Compact design, all components can be integrated into the fermentation system. You can choose the direct coupling mechanical stirring mode of upper drive or the indirect coupling mechanical stirring mode of lower drive magnetic, which has simple structure and stable operation.

Diameter-to-height ratio: 1:1~2.5; Liquid Charging Coefficient: 70%

Tank: 316L stainless steel, easy to clean; Stainless steel internal polishing accuracy Ra≤0.4;

Tank function: inlet sterilization filter, exhaust condenser, including intake and exhaust treatment system, motor: special SEW AC motor for fermenter; Double-pass sealing at the upper shaft end or magnetic stirring at the lower shaft to ensure zero leakage

Ventilation: Multi-channel ventilation is adopted, and the air flow rate and oxygen flow rate are automatically controlled by the thermal mass flow meter

Pressure: Pressure control range: 0-0.3Mpa, pressure regulating valve adjusts the outlet pressure, digital remote display.

Mixing system: Stirring type: straight and inclined blade stirring paddle (multi-stage)

Fermentation pH control function: intelligent PID control, METTLER PH electrode;

Fermentation dissolved oxygen control function: intelligent PID control, METTLER DO electrode;

Temperature control: intelligent PID control, electric heating, water cooling, circulating pump circulating temperature control,

Feeding: perfect feeding system (acid, alkali, bubble, culture agent)

Exhaust: The exhaust is discharged by heating filtration inactivation

Fermentation broth weighing system: in-line detection of fermentation volume* (weight), weighing sensor*METTLER (Load cell)

JIP Tank Cap Automatic Lifting System: Tank lid automatic lifting system, easy to clean and maintain

BLBIO-SIP tank automatic sterilization system: automatic program sterilization, reduce labor intensity, improve sterilization accuracy

BLBIO-CIP Tank Automatic Cleaning System: Tank Automatic Cleaning System

BLBIO-D type control system optional: Siemens S7-200 series PLC+12-inch tablet computer touch screen display, on-site direct operation (menu type), full Chinese menu and interface; It can also be used with the host computer for data transmission, sampling and display of tank data, browsing and analysis of system data, and reading settings. Control or collect pH, DO, tank pressure, temperature, speed, air flow, feed weighing, fermentation liquid volume and other parameters, and can easily calibrate pH and DO electrodes through software; set the initial control state of the parameters; It has an independent curve analysis system; Analyze historical curves directly

Technical parameters

Stirring speed: special motor for fermentation tank, speed: 50~1000rpm stepless speed change; Accuracy: ±1rpm;

PH control: intelligent PID control, automatic acid/alkali supplement; Range: 2~12ph; Control accuracy: ±0.02ph,

DO control: intelligent PID control, which is related to feeding, speed, air flow and pressure; Range: 0~100%, Control accuracy: ±3%;

Temperature control: intelligent PID control; Electrically heated water cooling; Range: cooling water temperature +5~80°C; Accuracy: ±0.1°C;

Foam control: peristaltic pump replenishment defoamer, automatic control;

Ventilation: automatic adjustment, digital display;

Tank pressure: automatic adjustment, digital display


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