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Metabolic Flow Bioreactor (Ideal for process development)
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Metabolic flow Bioreactor(ideal for process development)
30L Advanced Metabolic Flow Fermenter BLBIO-30FMT
30L3 Combined Metabolic Flow Fermenter BLBIO-30FMT-3
15L15L50L metabolic flow fermenter BLBIO-15FMT-15FMT-50FMT
50L8 Combined Metabolic Flow Fermenter BLBIO-50FMT-8 316L stainless steel tank, no dead angle of the tank, spherical tank bottom head, can obtain better fluid performance, the best mixing effect. The long glass sight glass is convenient for observing the state in the tank, and the special design of the mirror lamp is a quick interface, which is convenient and safe to operate. Standard pH, DO, and temperature interfaces are reserved, and aseptic sampling and discharge ports are designed with multi-valve combinations, and the top of the tank includes inoculation ports, feeding ports, foam electrode interfaces, exhaust condenser interfaces, and multiple backup ports. The pipeline valves are made of stainless steel, and the special sanitary pipeline valves for food and fermentation simplify the pipeline design and reduce the chance of infection under the premise of realizing complete functions Stirring mode, using direct transmission mechanical stirring or magnetic transmission mechanical stirring, stepless speed regulation, can run stably at lower and higher speeds, will not appear idling or slipping, and accurate speed measurement. The standard type of stirring impeller is closed six-blade, and there are many other types of impellers to choose from, such as pitch-blade propellers, turboprops, arrow blades, spiral blades, open six-blades, etc. The impeller position can be adjusted and can be freely combined with other paddle types to obtain the best fluid type. Reasonable baffle design can effectively eliminate the vortex generated during stirring, and can obtain a higher secondary flow, so that the heat and mass transfer rate can be greatly improved. Volume: 5L-5000L, the analysis of molecular metabolic flow in the fermenter can be carried out by detecting the parameters of fermentation heat OUR, CER, RQ, KLa, etc Pressure: Pressure control range: 0-0.3Mpa, pressure regulating valve adjusts the outlet pressure, digital remote display. Stirring system: Stirring form: straight and inclined blade stirring paddle (multi-stage) SEW motor, using direct coupling mechanical stirring mode of upper drive or indirect coupling mechanical stirring mode of lower drive magnetic, simple structure and stable operation Fermentation pH control function: intelligent PID control, METTLER PH electrode; Fermentation dissolved oxygen control function: intelligent PID control, METTLER DO electrode; Temperature control: intelligent PID control, electric heating, water cooling, circulating pump circulating temperature control, Feeding: perfect feeding system (acid, alkali, bubble enemy, culture agent), electronic balance weighing to control the amount of feeding Fermentation broth weighing system: in-line detection of fermentation volume* (weight), weighing sensor*Load cell outputs electrical signal BLBIO-GC9000 on-line detection of O2 and CO2 content in tail gas (optional): Hartmann (Germany) tail gas analyzer is used to detect CO2 and O2 content in fermentation tail gas online, and the direction of metabolic flow such as respiratory quotient can be carried out through the volume of fermentation liquid combined with ventilation, and the data can be automatically recorded and saved for query and analysis. BLBIO-JIP Tank Cap Automatic Lifting System (Optional) BLBIO-SIP Automatic Tank Pipeline Sterilization System (Optional) BLBIO-CIP Automatic Tank Cleaning System (Optional) BLBIO-type A, B, C, D type control system optional: Siemens S7-200 series PLC control system, it is a mature, stable and general-purpose PLC, which can be suitable for various applications of automation, especially in the application of manufacturing process control. With its modularity, easy-to-achieve distributed configuration and easy-to-master characteristics, Siemens PLC control core has become an economical and advanced control system for the implementation of biological reaction process control. The system uses a tablet computer of more than 10 inches to control or collect 17 direct parameters such as pH, DO, tank pressure, temperature, speed, air flow, exhaust O2, exhaust CO2, feeding weighing, fermentation liquid volume, etc., and can calculate indirect parameters. pH and DO electrodes can be easily calibrated by software; Set the initial control state of the parameters (the demander must be equipped with an exhaust gas analyzer). BLBIO-FS8.0 is based on the theory of detection and control of cell and molecular biometabolic flux and has been rich in the detection and control of microbial fermentation process optimization research for many years. The main functions of this software are as follows: A: Accurately calculate indirect parameters such as OUR, CER, RQ, KLa and other online parameters, and can display multiple curves with different parameters on the same coordinate plane at the same time; B: Accurately display the material balance and changes in the fermenter, which is convenient for users to analyze the correlation of the fermentation process, so as to help users derive appropriate control points and achieve the purpose of one-step scale-up of pilot test; C: It can input the detection data of total sugar, reducing sugar, amino nitrogen, bacterial concentration, fermentation unit and other offline and generate the corresponding curve under the online process parameter curve; D: It mainly has the following functions: Parallel sampling of multiple tanks Direct comparison of multi-batch data Unified display and comprehensive analysis of multiple data Convenient customization capability (can be programmed by yourself) Real-time sampling of online data Real-time processing and display of online data Manual parameter input Indirect parameters are automatically calculated Historical data query and display Custom parameters Graphics, report printing This equipment and software are relatively high-end products developed by our company, which are suitable for large-scale pharmaceutical factories and research institutes to optimize the process
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