Automatic Bioreactor (GMP)

Stainless steel tank, the contact material part is 316L stainless steel, the tank body has no dead angle, and the spherical tank bottom head
Stirring method: the upper drive direct coupling mechanical stirring or the lower drive magnetic indirect coupling mechanical stirring mode, simple structure, stable operation
Sterilization method: BLBIO-SIP automatic program sterilization (leading technology, stable quality, low failure rate, reduce the labor intensity of the operator).
Temperature: cooling water temperature +5°C~80°C± 0.2°C tap water or ice water cooling, external circulation heating, avoid local overheating, stable temperature control.
pH: 2.00~12.00±0.05 Two peristaltic pumps two-way switch control
DO: 0~100%±3%
stirring: 50~1000rpm±10% stepless speed regulation, shaft transmission mechanical stirring or magnetic transmission mechanical stirring
feeding: peristaltic pump duty cycle switch control
Defoaming: sensitivity 100~100,000 Ω electrode detection, peristaltic pump duty cycle switch control to add defoamer

BLBIO-B-type, C-type, S-type control system optional: Siemens S7-200 series PLC control system, it is a mature, stable and general-purpose PLC, which can be suitable for various applications of automation, especially in the application of manufacturing process control. With its modularity, easy-to-achieve distributed configuration and easy-to-master characteristics, Siemens PLC control core has become an economical and advanced control system for the implementation of biological reaction process control. The system uses more than 10-inch tablet computer to control 7 direct parameters such as pH, DO, tank pressure, temperature, speed, defoaming, feeding, etc., and the automatic sterilization process of the tank pipeline can easily calibrate the pH and DO electrodes through software; Initial control state of set parameters BLBIO-8.0 analysis software is based on the theory of detection and control of cell and molecular biometabolic flux and has been rich in microbial fermentation process optimization research for many years. The functions of this software are mainly as follows: A: Accurately calculate indirect parameters such as OUR, CER, RQ, KLa and so on, and can display a number of curves with different parameters on the same coordinate plane at the same time; B: Accurately display the material balance and changes in the fermenter, which is convenient for users to analyze the correlation of the fermentation process, so as to help users derive appropriate control points and achieve the purpose of one-step scale-up of pilot test; C: It can input the detection data of total sugar, reducing sugar, amino nitrogen, bacterial concentration, fermentation unit and other offline and generate the corresponding curve under the online process parameter curve; D: It mainly has the following functions: multi-tank parallel sampling, multi-batch number data direct comparison, unified display and comprehensive analysis of multiple data, convenient self-customization ability (you can program it yourself), online data real-time sampling, online data real-time processing and displayManual parameter input, indirect parameter automatic calculation, data query and display of custom parameter graphics, report printing This equipment is a relatively high-end product developed by our company, suitable for large-scale pharmaceutical factories and research institutes to optimize the process

Add optional features:

b. Feeding balance weighing W Tank weighing D Automatic control of air flow e Tank pressure detection f Bypass pure oxygen g On-line detection of redox potential h On-line detection and control of methyl (ethyl) alcohol content I On-line detection of tail gas O2 and CO2 content A Automatic sterilization function C. Automatic tank cleaning function U Automatic lifting function of tank cover